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Angélica Ángeles-Llerenas1, James F Thrasher2, Rosalinda Domínguez-Esponda3

  • 1Comité de Ética de Investigación, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, Mexico.. aangelica@insp.mx.

Salud Publica De Mexico
|April 19, 2022
PubMed
Summary

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This summary is machine-generated.

Research Ethics Committees (RECs) in Mesoamerica face significant infrastructure and staffing challenges. Investments in training and resources are crucial for ethical research conduct and participant protection.

Area of Science:

  • Bioethics
  • Public Health Research
  • Latin American Studies

Background:

  • Research Ethics Committees (RECs) are vital for safeguarding participants in clinical research.
  • Understanding REC operations in low- and middle-income countries (LMICs) is essential for improving research integrity.
  • The Mesoamerican region presents unique challenges for ethical oversight in research.

Purpose of the Study:

  • To assess the operational practices, training needs, and infrastructure of RECs in Mesoamerica.
  • To identify key challenges hindering the effective functioning of RECs in the region.

Main Methods:

  • An online survey was administered to 55 Research Ethics Committees across Colombia, Costa Rica, Guatemala, and Mexico.
  • The survey focused on operational practices, training requirements, and available infrastructure for REC functions.

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Main Results:

  • A significant proportion of RECs reported inadequate infrastructure, with less than half having dedicated office space for file management.
  • Insufficient administrative staff and financial resources for active site monitoring were commonly reported issues.
  • These deficiencies impact the ability of RECs to ensure the protection of study participants' rights and welfare.

Conclusions:

  • Substantial investment in REC member training and infrastructure development is urgently required.
  • Enhancing REC capabilities is critical for ensuring compliance with ethical research standards.
  • Strengthening RECs is paramount for upholding the ethical conduct of research in Mesoamerica.