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Focused update: Guidelines of care for the management of actinic keratosis

Daniel B Eisen1, Robert P Dellavalle2, Lindsy Frazer-Green3

  • 1Department of Dermatology, University of California, Davis, Sacramento, California.

Journal of the American Academy of Dermatology
|April 19, 2022
PubMed
Abstract

Insights

Topical tirbanibulin is strongly recommended for treating actinic keratoses (AKs), a common skin condition caused by sun exposure. This guideline update incorporates new evidence for managing AKs effectively.

Area of Science:

  • Dermatology
  • Oncology
  • Evidence-based medicine

Background:

  • Actinic keratoses (AKs) are precancerous skin lesions resulting from chronic UV exposure.
  • AKs can potentially progress to keratinocyte carcinoma, a type of skin cancer.

Purpose of the Study:

  • To update clinical guidelines for managing AKs.
  • To evaluate the efficacy and safety of topical tirbanibulin for AK treatment based on recent evidence.

Main Methods:

  • A systematic review of available data on topical tirbanibulin for AK.
  • Application of the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.
  • Multidisciplinary work group consensus through voting on the recommendation.

Main Results:

  • Two clinical trials were identified and analyzed.
  • A single, strong clinical recommendation was formulated based on the evidence.

Conclusions:

  • Topical tirbanibulin is recommended as a treatment option for actinic keratoses.
  • This recommendation is based on the best available evidence, though long-term data are pending.
Keywords:
actinic keratosisactinic keratosis guidelinesclinical guidelines for actinic keratosistirbanibulintopical agents

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