Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.8K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.8K
Hand hygiene01:23

Hand hygiene

4.3K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
4.3K
Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

7.4K
Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
7.4K
Phases of Wound Repair01:28

Phases of Wound Repair

6.5K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.5K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.3K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.3K
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

2.6K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ASO Visual Abstract: The Added Value of Plastic Surgery in the Multidisciplinary Management of Sarcoma Resection: A Multivariable Analysis of Predictors and Postoperative Outcomes.

Annals of surgical oncology·2026
Same author

The Added Value of Plastic Surgery in the Multidisciplinary Management of Sarcoma Resection: A Multivariable Analysis of Predictors and Postoperative Outcomes.

Annals of surgical oncology·2026
Same author

Does enzymatic debridement reduce the occurrence of hypertrophic scarring in intermediate depth burns?

Burns : journal of the International Society for Burn Injuries·2025
Same author

Correction: Rijpma et al. Wound and Short-Term Scar Outcomes of Meek Micrografting Versus Mesh Grafting: An Intra-Patient Randomized Controlled Trial. <i>Eur. Burn J.</i> 2025, <i>6</i>, 26.

European burn journal·2025
Same author

Wound and Short-Term Scar Outcomes of Meek Micrografting Versus Mesh Grafting: An Intra-Patient Randomized Controlled Trial.

European burn journal·2025
Same author

Validity of laser speckle contrast imaging for predicting wound healing potential in burns: A critical examination.

Burns : journal of the International Society for Burn Injuries·2025

Related Experiment Video

Updated: Sep 26, 2025

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings
09:37

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Published on: December 4, 2021

8.2K

Enzymatic debridement: past, present, and future.

Ignace De Decker1, Liesl De Graeve2, Henk Hoeksema1,2

  • 1Burn Center, Ghent University Hospital, Ghent, Belgium.

Acta Chirurgica Belgica
|April 20, 2022
PubMed
Summary
This summary is machine-generated.

Enzymatic debridement, particularly with bromelain-based products like NexoBrid®, offers a selective alternative to surgical debridement for deep burns. Further trials are needed to fully establish its role compared to standard care.

Keywords:
Burnchemical debridementenzymatic debridementnon-surgical debridementtangential excision

More Related Videos

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

7.6K
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

21.7K

Related Experiment Videos

Last Updated: Sep 26, 2025

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings
09:37

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Published on: December 4, 2021

8.2K
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

7.6K
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

21.7K

Area of Science:

  • Burn wound management
  • Dermatology
  • Surgical innovation

Background:

  • Surgical debridement is the standard of care for deep burns but has limitations.
  • Enzymatic debridement is emerging as a less invasive alternative.
  • Interest is growing in non-surgical debridement methods.

Purpose of the Study:

  • To provide a historical overview and current state of enzymatic debridement for burns.
  • To evaluate enzymatic debridement as an alternative to surgical debridement.
  • To discuss future perspectives in non-surgical burn wound treatment.

Main Methods:

  • A systematic search of the literature was conducted.
  • A narrative review of 32 selected articles was performed.

Main Results:

  • Bromelain-based enzyme mixtures are currently used for burn eschar removal.
  • Enzymatic debridement selectively removes eschar in deep burns, potentially reducing skin grafting needs.
  • Off-label use of NexoBrid® for facial, pediatric, and large burns (>15% TBSA) is effective and safe.

Conclusions:

  • NexoBrid® facilitates selective eschar removal, often under regional anesthesia.
  • Optimal clinical wound bed evaluation post-NexoBrid® and treatment decisions require further study.
  • High-quality trials are needed to compare enzymatic debridement with standard care regarding effectiveness, surgical necessity, healing time, and scar quality.