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Published on: May 30, 2025
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LncRNA SBF2-AS1: A Budding Star in Various Cancers
Fangshun Tan1,2, Jinlan Chen1,2, Bei Wang1,2
1Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
Current Pharmaceutical Design
|April 20, 2022
Summary
Long non-coding RNA SBF2-AS1 is implicated in numerous cancers. This review summarizes its mechanisms for potential targeted cancer therapies.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides.
- lncRNAs play critical roles in various stages of tumor progression.
- lncRNA SBF2-AS1 is an oncogenic lncRNA involved in multiple cancer types.
Purpose of the Study:
- To review the mechanisms of lncRNA SBF2-AS1 in various cancers.
- To explore the therapeutic potential of lncRNA SBF2-AS1 in targeted cancer treatment.
Main Methods:
- Literature review of studies on lncRNA SBF2-AS1 and cancer.
- Analysis of the molecular mechanisms underlying lncRNA SBF2-AS1's role in tumorigenesis, proliferation, migration, invasion, metastasis, and angiogenesis.
- Compilation of evidence regarding lncRNA SBF2-AS1's involvement in specific cancer types.
Main Results:
- lncRNA SBF2-AS1 is overexpressed in various cancers, including AML, breast cancer, ccRCC, CRC, and lung cancer.
- lncRNA SBF2-AS1 promotes cancer progression through diverse molecular pathways.
- lncRNA SBF2-AS1 is associated with cancer diagnosis, treatment response, and prognosis.
Conclusions:
- lncRNA SBF2-AS1 is a significant oncogenic factor across a wide spectrum of cancers.
- Understanding lncRNA SBF2-AS1's mechanisms can lead to novel targeted therapeutic strategies.
- Further research into lncRNA SBF2-AS1 holds promise for advancing precision oncology.
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