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Updated: Sep 26, 2025

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Hepatitis C Virus Exposure and Infection in the Perinatal Period

Mine Varol1, Ndeye Licka Dieye1,2, Michael Zang3

  • 1Department of Pediatrics, Division of Pediatric Infectious Diseases, International Enteric Vaccine Research Program (IEVRP), University at Buffalo, State University of New York, Buffalo, NY, USA.

Current Pediatric Reviews
|April 20, 2022
PubMed

Insights

Hepatitis C virus (HCV) infection disproportionately affects underserved communities. Early screening and treatment for mothers and infants are crucial to prevent chronic hepatitis C and its complications.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection is a major global cause of liver disease.
  • Untreated hepatitis C can lead to severe complications like cirrhosis and liver cancer.
  • HCV poses a significant risk to infants born to infected mothers.

Purpose of the Study:

  • To review the epidemiology of hepatitis C in perinatally exposed children.
  • To examine clinical features, diagnosis, and treatment strategies.
  • To assess prevention methods for hepatitis C in this vulnerable population.

Main Methods:

  • Searched public databases (MEDLINE, PubMed) for relevant articles.
  • Included data from major health organizations (CDC, FDA, WHO, NIH).
  • Focused on literature published between 2006 and 2021.

Main Results:

  • HCV prevalence is rising in US women of childbearing age, linked to drug use and socioeconomic factors.
  • Vertical transmission risk is 6%, with 75% of infected infants developing chronic hepatitis C.
  • Delayed diagnosis and follow-up increase risks for complications in exposed infants.

Conclusions:

  • Hepatitis C disproportionately impacts underserved communities.
  • Early screening of mothers and infants is vital for timely diagnosis and treatment.
  • Policy changes are needed to address healthcare inequities in maternal and infant HCV care.
Abstract

Keywords:
Hepatitis CUnited States.exposureinfantsperinatalpreventiontreatment

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