Related Experiment Video

Updated: Sep 26, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

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Dysregulated Epigenetics of Chordoma: Prognostic Markers and Therapeutic Targets

Kevin Tu1,2, Sang Lee3, Sanjit Roy1

  • 1Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.

Current Cancer Drug Targets
|April 20, 2022
PubMed

Insights

Chordoma, a rare bone cancer, presents treatment challenges due to therapy resistance. This review explores epigenetic factors driving chordoma and their potential as biomarkers and therapeutic targets.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Chordoma is a rare, slow-growing sarcoma with limited therapeutic options.
  • It is locally aggressive and often resistant to conventional chemo- and radiotherapy.
  • Current understanding of chordoma pathogenesis and therapy resistance mechanisms is limited.

Purpose of the Study:

  • To review the current understanding of epigenetic drivers in chordoma.
  • To explore the potential of epigenetic modifications as prognostic biomarkers.
  • To discuss the development of novel therapies targeting epigenetic pathways in chordoma.

Main Methods:

  • Literature review of studies on chordoma epigenetics.
  • Analysis of whole-genome sequencing data in chordoma.
  • Discussion of potential therapeutic strategies targeting epigenetic alterations.

Main Results:

  • Chordoma exhibits a low mutation rate, suggesting a significant role for epigenetic alterations.
  • Epigenetic dysregulation is implicated in chordoma pathogenesis and progression.
  • Specific epigenetic modifications may serve as predictive or prognostic biomarkers.

Conclusions:

  • Epigenetic mechanisms are crucial in chordoma development and resistance to therapy.
  • Targeting epigenetic pathways offers promising avenues for novel chordoma treatments.
  • Further research into chordoma epigenetics is essential for improving patient outcomes.
Keywords:
ChordomaDNA methylationbiomarkersepigeneticshistone modificationslncRNAmiRNAprognosis

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