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Updated: Sep 26, 2025

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
Device-related thrombus following left atrial appendage occlusion
Trevor J Simard1, Benjamin Hibbert2, Mohamad A Alkhouli1
1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Abstract:
Thrombus formation on intracardiac devices remains a subject of importance, with rates in the 2-5% range. Device-related thrombus (DRT) following left atrial appendage occlusion is an area of particular concern considering its association with embolic events. DRT continues to present numerous questions, including the optimal definition, incidence, risk factors, monitoring, therapy, and clinical outcomes - all subjects of ongoing assessment. Herein, we discuss these considerations, building upon the relevant historical context and pathophysiologic insights while discussing the future considerations in this rapidly evolving field.
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