Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures
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Hengxin Feng1, Chun Kit Kwok1,2
1Department of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon Tong Hong Kong SAR China ckkwok42@cityu.edu.hk +852 3442 0522 +852 3442 6858.
RSC Chemical Biology
|April 20, 2022
Abstract:
We study and uncover the effect of hairpin structures in loops of G-quadruplexes using spectroscopic methods. Notably, we show that the sequence, structure, and position of the hairpin loop control the spectroscopic properties of long loop G-quadruplexes, and highlight that intrinsic fluorescence can be used to monitor the formation of non-canonical G-quadruplexes.

