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Isolation and Expansion of Human Glioblastoma Multiforme Tumor Cells Using the Neurosphere Assay
Published on: October 30, 2011
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Primary spinal cord glioblastoma multiforme: a single-center experience
Shaurya Darbari1, Nivedita Manjunath1, Ramesh Sharanappa Doddamani1
1Department of Neurosurgery and Neuropathology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
British Journal of Neurosurgery
|April 20, 2022
Summary
Primary spinal glioblastoma (GBM) is rare, but whole craniospinal axis radiotherapy and chemotherapy with temozolomide (TMZ) significantly improve survival. Early diagnosis and imaging are crucial for managing these aggressive spinal cord tumors.
Area of Science:
- Neuro-oncology
- Spinal Cord Tumors
- Glioblastoma Research
Background:
- Primary spinal glioblastoma (GBM) is exceptionally rare, posing significant management challenges.
- These tumors have a poor prognosis, and established treatment guidelines are lacking.
Purpose of the Study:
- To develop treatment guidelines for primary spinal GBM.
- To analyze institutional experience and literature data for rare spinal cord tumors.
Main Methods:
- Retrospective study of primary spinal GBM patients from 2008-2020.
- Inclusion of patients who underwent surgery, with data from case files and follow-up.
- Analysis of postoperative chemoradiation, histopathology, and survival outcomes.
Main Results:
- Median survival of 11 months in nine followed patients.
- Chemotherapy (TMZ) and whole craniospinal axis radiotherapy improved survival.
- Surgical resection extent was not significant; intracranial metastasis was a leading cause of mortality.
Conclusions:
- Prompt diagnosis of high-grade spinal cord tumors is essential.
- Whole craniospinal axis imaging and radiotherapy are recommended for spinal GBM.
- Early detection and management of intracranial metastasis are critical for survival.
