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Updated: Sep 26, 2025

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy
Published on: May 22, 2020
Meningeal Lymphatic vasculature in health and disease
Nisha Busch1, Liam O'Reilly1, Antoine Louveau2,3,4
1Neuroscience Undergraduate Program, Case Western Reserve University.
Purpose Of Review:
The recent (re)discovery of the meningeal lymphatic has brought a new player in brain neurophysiology. This review highlights the state of the current research on the meningeal lymphatic vasculature, from its specific physiology to its increasing implication in normal and pathological brain function.
Recent Findings:
Growing evidence are emerging about the uniqueness of the meningeal lymphatic vasculature and its implication in multiple neurological and neurotraumatic disorders.
Summary:
These studies are highlighting a new and unexpected role for the lymphatic vasculature in brain function and a potential new therapeutic target for neurological disorders.
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