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Primary nervous system lymphoma in cats.

Daniel R Rissi1, Brittany J McHale2, Andrew D Miller3,4

  • 1Athens Veterinary Diagnostic Laboratory, Department of Pathology.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|April 20, 2022
PubMed
Summary

This study analyzed 10 feline primary nervous system lymphoma cases, finding equal B-cell and T-cell origins. Ataxia was the most common sign, with lymphomas affecting the brain and spinal cord.

Keywords:
braincatslymphomanerveneuropathologyspinal cord

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Area of Science:

  • Veterinary Neurology
  • Comparative Pathology
  • Oncology

Background:

  • Primary nervous system lymphoma is a significant neoplastic disease in domestic animals.
  • Characterizing feline central nervous system lymphoma is crucial for diagnosis and treatment.

Purpose of the Study:

  • To detail the neuroanatomic distribution, neuropathology, and immunophenotype of primary nervous system lymphoma in cats.
  • To differentiate between B-cell and T-cell lymphomas in affected felines.

Main Methods:

  • Retrospective review of 10 feline cases from two academic institutions.
  • Immunohistochemistry (IHC) analysis using CD3, CD20, and Pax5 markers.
  • Histopathological examination of affected tissues.

Main Results:

  • Mean age of affected cats was 9.1 years; no sex or breed predilection observed.
  • Ataxia was the most frequent clinical sign (8/10 cases).
  • Lymphomas occurred in the brain, spinal cord, and nerves, with equal distribution between B-cell (5/10) and T-cell (5/10) types.

Conclusions:

  • Feline primary nervous system lymphoma presents with diverse neuroanatomic distributions and histopathological features.
  • Immunophenotyping confirmed an equal prevalence of B-cell and T-cell lymphomas.
  • Further research into targeted therapies based on immunophenotype is warranted.