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Transaminase Elevation in Nutritional Infantile Failure to Thrive
Kristen A Marten1, Nicole E St Clair2, Daniel M O'Connell2
1Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, KMarten@uwhealth.org.
Summary
Mild transaminase elevations are common in infants with failure to thrive (FTT) due to poor nutrition. These elevations typically do not require further investigation, as no alternative diagnoses were found.
Area of Science:
- Pediatrics
- Clinical Chemistry
Background:
- Laboratory investigations for infants with failure to thrive (FTT) frequently reveal mild transaminase elevations.
- The incidence and clinical significance of these elevations in FTT infants remain largely unknown.
Purpose of the Study:
- To determine the significance of mild transaminase elevations in infants diagnosed with failure to thrive.
Main Methods:
- A retrospective chart review was conducted on infants diagnosed with simple nutritional FTT.
- Diagnostic studies and outcomes were compared between infants with and without transaminase elevation using statistical tests.
Main Results:
- No infants with abnormal transaminases required additional follow-up after the initial diagnosis.
- No alternative diagnoses were identified in infants with elevated transaminases during the subsequent year.
Conclusions:
- Mild transaminase elevations are potentially common in infants with failure to thrive.
- Isolated transaminase elevations in FTT infants with a clear nutritional etiology may not necessitate further diagnostic workup.
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