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Rational Mitomycin Nanocarriers Based on Hydrophobically Functionalized Polyelectrolytes and
Łukasz Lamch1, Kazimiera A Wilk1, Imre Dékány2
1Department of Engineering and Technology of Chemical Processes, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, Wrocław 50-370, Poland.
Langmuir : the ACS Journal of Surfaces and Colloids
|April 20, 2022
Summary
Developing novel core-shell nanoparticles enhances hydrophilic drug delivery. Hydrophobically functionalized polyelectrolytes improve drug stability and controlled release, crucial for effective nanocarrier systems.
Area of Science:
- * Pharmaceutical Nanotechnology
- * Polymer Chemistry
- * Drug Delivery Systems
Background:
- * Encapsulating hydrophilic and amphiphilic drugs for sustained release presents challenges due to solubility and polymer compatibility issues.
- * Traditional nanocarriers struggle with effective delivery of water-soluble or amphiphilic compounds.
- * A core-shell nanocarrier approach offers a solution by creating distinct internal and external microenvironments.
Purpose of the Study:
- * To develop colloidally stable poly(lactic-co-glycolic) acid (PLGA) nanoparticles for sustained mitomycin C (MMC) delivery.
- * To utilize hydrophobically functionalized polyelectrolytes (HF-PEs) as shell-forming materials for enhanced drug stability and controlled release.
- * To investigate the impact of different HF-PEs on payload chemical stability and nanocarrier performance.
Main Methods:
- * Nanoparticles were prepared using the nanoprecipitation method, encapsulating PLGA in acetone.
- * Aqueous solutions containing HF-PEs, specifically poly(4-styrenesulfonic-co-maleic acid) and poly(acrylic acid) derivatives, were used for shell formation.
- * The hydrophilic-lipophilic balance (HLB) of HF-PEs was varied to assess their effect on nanoparticle properties and drug stability.
Main Results:
- * The choice of HF-PE significantly impacted the chemical stability of mitomycin C (MMC).
- * Poly(acrylic acid) derivatives led to rapid MMC hydrolysis, while poly(4-styrenesulfonic-co-maleic acid) demonstrated superior stability.
- * Core-shell nanoparticles stabilized by HF-PEs showed potential for enhanced payload chemical stability and sustained release profiles.
Conclusions:
- * Hydrophobically functionalized polyelectrolytes are effective shell-forming materials for creating stable core-shell nanocarriers.
- * The selection of appropriate HF-PEs is critical for preserving the chemical integrity of encapsulated hydrophilic drugs like MMC.
- * This study provides valuable insights into optimizing nanocarrier design for improved drug delivery and stability.
