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Related Experiment Video

Updated: Sep 26, 2025

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
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Toward more streamlined testing in pediatric oncology.

Michael F Walsh1

  • 1Divisions of Solid Tumor and Clinical Genetics, Departments of Medicine and Pediatrics, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.

Science Advances
|April 20, 2022
PubMed
Summary
This summary is machine-generated.

Gene sequencing of blood plasma can detect both cancer and infections in children with leukemia. This blood test offers a simultaneous diagnostic approach for complex pediatric cases.

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Genomics
  • Pediatrics

Background:

  • Pediatric leukemia patients often face co-infections and disease progression, complicating treatment.
  • Accurate and timely diagnosis of both cancer and concurrent infections is critical for effective management.

Purpose of the Study:

  • To evaluate the utility of gene sequencing on blood plasma for the simultaneous detection of cancer and infectious agents in pediatric leukemia.
  • To explore a novel diagnostic approach for improving patient outcomes.

Main Methods:

  • Utilized advanced gene sequencing techniques on plasma samples from pediatric leukemia patients.
  • Developed bioinformatics pipelines for identifying both malignant and microbial DNA signatures.

Main Results:

  • Successfully demonstrated the simultaneous detection of leukemia-specific genetic alterations and pathogens.
  • Identified specific cancer mutations and infectious agents in a single plasma sample.

Conclusions:

  • Plasma gene sequencing presents a promising, non-invasive method for the concurrent diagnosis of cancer and infection in pediatric leukemia.
  • This approach could streamline diagnostics and guide personalized treatment strategies.