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Urinary Bladder Matrix Improves Irradiated Wound Healing in a Murine Model
Jingxin Yao1, Kella L Vangsness1, Phillip Khim1
1From the Division of Plastic and Reconstructive Surgery, Keck School of Medicine of University of Southern California, University of Southern California, Los Angeles.
Annals of Plastic Surgery
|April 20, 2022
Summary
Topical urinary bladder matrix (UBM) significantly accelerates healing in chronic radiation-induced skin wounds. This biologically based therapy promotes better wound reepithelialization and collagen deposition, offering a promising noninvasive treatment option.
Area of Science:
- Regenerative Medicine
- Wound Healing Biology
- Biomaterials Science
Background:
- Radiation skin damage often results in chronic wounds with impaired healing.
- Current localized treatments for radiation-induced wounds offer limited efficacy.
- Biologically based solutions are being explored for improved therapeutic outcomes.
Purpose of the Study:
- To investigate the therapeutic effect of topical urinary bladder matrix (UBM) on chronic irradiated skin wounds.
- To evaluate UBM's impact on wound closure rates and histological characteristics in a murine model.
Main Methods:
- Utilized an established murine model of chronic irradiated skin wounds.
- Applied topical urinary bladder matrix (UBM) as a treatment modality.
- Assessed wound healing progression through macroscopic observation and histological analysis.
- Quantified gene expression of profibrotic mediators using real-time polymerase chain reaction.
Main Results:
- Topical UBM significantly accelerated wound healing at days 7, 14, and 21 (P < 0.05).
- Histological examination revealed enhanced wound reorganization, reepithelialization, increased myofibroblast density (P = 0.0004), and collagen deposition (P < 0.0001).
- UBM treatment led to decreased expression of profibrotic mediators (P = 0.0049).
Conclusions:
- Topical urinary bladder matrix (UBM) is an effective adjunctive therapy for chronic irradiated skin wounds.
- UBM promotes accelerated healing, improved tissue regeneration, and modulates fibrotic pathways.
- This noninvasive approach shows potential for clinical application in managing radiation-induced skin damage.
