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Correlation of Troponin I with Left Ventricular Ejection Fraction in Acute Coronary Syndrome
Neeraja Mohan1, K M Shivakumar1, Chethan Kumar Kl1
1Mandya Institute of Medical Sciences, Mandya.
Insights
This study found a strong negative correlation between Troponin I levels and left ventricular ejection fraction in acute coronary syndrome patients. Higher Troponin I indicates poorer heart function, useful for predicting LVEF.
Area of Science:
- Cardiology
- Biomarkers
- Cardiac Injury
Background:
- Coronary artery disease is a leading cause of death globally, with cardiovascular disease (CVD) projected to cause 33% of all deaths by 2030.
- Myocardial necrosis releases intracellular macromolecules, making cardiac troponin the preferred biomarker for detecting heart muscle injury due to its sensitivity and specificity.
- Acute coronary syndrome (ACS) represents a critical manifestation of coronary artery disease requiring prompt diagnosis and management.
Purpose of the Study:
- To investigate the correlation between Troponin I levels and left ventricular ejection fraction (LVEF) in patients experiencing acute coronary syndrome.
- To establish Troponin I as a predictive biomarker for assessing left ventricular function in ACS.
- To enhance the understanding of myocardial injury markers in cardiovascular disease prognosis.
Main Methods:
- A prospective observational study was conducted on 75 patients diagnosed with ACS who provided informed consent.
- Data collected included patient demographics, medical history, daily ECG, serum Troponin I levels, and left ventricular ejection fraction measured by echocardiography on the 4th hospital day.
- Left ventricular ejection fraction was categorized as normal (>50%), mildly reduced (40-50%), or reduced (<40%).
Main Results:
- The study observed a mean Troponin I level of 8332.47 (SD=8371.17), with values ranging from 23 to 32000.
- A significant negative correlation (Pearson's r = -0.739, p < 0.001) was found between maximum Troponin I levels and left ventricular ejection fraction.
- These findings indicate that elevated Troponin I levels are strongly associated with reduced left ventricular function in ACS patients.
Conclusions:
- Serum Troponin I levels exhibit a strong negative correlation with left ventricular ejection fraction in patients with acute coronary syndrome.
- Troponin I can serve as a valuable predictive biomarker for estimating LVEF in the context of ACS.
- This correlation underscores the utility of Troponin I in assessing the severity of myocardial injury and guiding patient management in ACS.
Abstract:
Coronary artery disease is the most common cause of heart disease and the single most important cause of premature death in the world.In 2001,CVD was responsible for 29% of all deaths and 14% of the 1.5 billion lost DALYs.By 2030,when population is expected to reach 8.2 billion,33%of all deaths will be caused by CVD. Over the last decade, cardiovascular disease(CVD) has become the single largest cause of death worldwide. Myocardial necrosis causes release of structural proteins and other intracellular macromolecules into the cardiac interstitium as a consequence of compromise of the integrity of cellular membranes. On the basis of improved sensitivity and superior tissue-specificity compared with the other available biomarkers of necrosis, cardiac troponin is the preferred biomarker for the detection of myocardial injury. Material and Objectives:
- To determine the correlation between Troponin I with left ventricular ejection fraction in acute coronary syndrome.
- Source of data: The patients with ACS, who gave written consent for the study, in the IP departments of General Medicine.
- Study Design: Prospective observational study.
- Sample size: 75.
- The present study were conducted on patients diagnosed with ACS. Data regarding patient characteristics including age, sex, gender as well as history of chronic heart disease were collected. Patients evaluated during the hospital stay using daily ECG, troponin I, Ejection fraction of left ventricle measured using echocardiography at the 4th day of admission and catergorised as normal (>50%), mildly reduced(40-50%)and reduced(<40%) EF ced(<40%).
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