Prevalence of Dysnatremia in Pulmonary Tuberculosis

Pulmonary tuberculosis is one of the common diseases with high prevalence of mortality and morbidity in developing countries. It is one of the rare pulmonary infections which can induce hyponatremia and it is important to recognise hyponatremia because of its potential hazards.

To assess the serum sodium levels in patients with pulmonary tuberculosis and to establish a relation between the serum sodium levels and its effect on illness in these patients.

This is a single-center prospective observational Study conducted on patients with Pulmonary Tuberculosis, irrespective of treatment, in the department of General Medicine, B. R. Ambedkar Medical College, Bangalore from August 2019 to June 2021after obtaining ethical clearance. A total of 100 patients were enrolled in the study who met the predefined inclusion criteria of age more than 18 years and having been diagnosed with active tuberculosis. The collected data was analysed using student's T test and Chi-Square Test and the analysis was done using SPSS software version 24.0.

The mean age was 46.46+/- 15.69, with majority of participants in the age group 46-60 years. Gender wise there was male preponderance in our study with 60%. The average serum sodium concentration in our study was 134.20 +/- 5.59 mmol/l, with 44% prevalence of hyponatremia and 4% SIADH Conclusion: Although mild hyponatremia was seen in more than 50% of patients, we found out that hyponatremia in pulmonary tuberculosis is detected in 44% of our patients with male preponderance. The predominant mechanism of hyponatremia was syndrome of inappropriate anti- diuretic hormone secretion (SIADH), which was present in 65% of cases with hyponatremia. Early detection and treatment of underlying electrolyte abnormality can potentially reduce mortality and morbidity associated with tuberculosis and reduce duration of hospitalization. Further research into the prevalence of potassium, magnesium and chloride abnormalities can add to the lacunae of knowledge.