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Updated: Sep 26, 2025

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Published on: May 31, 2021
Rapid Desensitization after a Type I Hypersensitivity Reaction to Ceftazidime/ Avibactam
Col Christopher A Coop1, Maj Joshua R Berg2
1Department of Allergy and Immunology at Wilford Hall, Ambulatory Surgical Center, San Antonio, Texas.
Background:
Frequent antibiotic use increases the risk of multidrug-resistant pathogen formation and hypersensitivity to antibiotics, including Type I hypersensitivity reactions.
Presentation:
We present a case of the first successful induction of tolerance procedure for the antibiotic ceftazidime/ avibactam. The patient developed immediate generalized urticaria and flushing on his first dose of ceftazidime/avibactam. He was able to tolerate a 12-step desensitization procedure that resulted in the clearance of his infection.
Conclusions:
Drug desensitization procedures are useful for patients with adverse drug reactions in which optimal alternatives are not available. This is the first case report demonstrating a successful rapid induction of tolerance for the antibiotic ceftazidime/avibactam.
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