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Inflammation in Cerebral Venous Thrombosis

Jiayue Ding1, Baoying Song2,3, Xiran Xie2,3

  • 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.

Frontiers in Immunology
|April 21, 2022
PubMed

Insights

Cerebral venous thrombosis (CVT) is linked to inflammation, with elevated neutrophil-to-lymphocyte ratio (NLR) indicating worse outcomes. COVID-19 infection and vaccination may also trigger CVT via inflammatory pathways, requiring further research.

Area of Science:

  • Neurology
  • Immunology
  • Vascular Medicine

Background:

  • Cerebral venous thrombosis (CVT) is a rare cerebrovascular disease impacting quality of life.
  • Inflammation, involving leukocytes, cytokines, and adhesion molecules, plays a key role in CVT.
  • Inflammatory factors worsen CVT-induced brain injury and prognosis.

Purpose of the Study:

  • To review the association between inflammation and CVT.
  • To highlight the role of peripheral blood inflammatory biomarkers in CVT.
  • To explore the link between COVID-19 and CVT through inflammation.

Main Methods:

  • Review of clinical observations and existing evidence.
  • Analysis of peripheral blood inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR) and lymphocyte count.
  • Examination of data related to COVID-19 infection and vaccination in CVT.

Main Results:

  • Peripheral blood inflammatory biomarkers, specifically NLR and lymphocyte count, are correlated with CVT.
  • Increased NLR and systemic immune-inflammation index (SII) are associated with poor patient outcomes.
  • COVID-19 infection and vaccination are implicated in CVT development via inflammatory responses.

Conclusions:

  • Inflammation is a significant factor in CVT initiation, progression, and outcome.
  • Peripheral inflammatory markers like NLR can predict CVT prognosis.
  • Further research is essential to fully understand the complex relationship between inflammation and CVT, especially concerning COVID-19.

Keywords:
COVID-19brain injurycerebral venous thrombosiscytokinesinflammation

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