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Related Experiment Video

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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

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Published on: August 18, 2020

Marijuana impacts mood in bipolar disorder: a pilot study.

Staci A Gruber¹, Kelly A Sagar¹, Mary K Dahlgren¹

¹Brain Imaging Centre, McLean Hospital, 115 Mill St, Belmont, MA, USA.

Mental Health and Substance Use : Dual Diagnosis

|April 21, 2022

Summary

Marijuana smoking significantly improved mood in bipolar patients who also smoke marijuana (MJBP). However, non-bipolar marijuana smokers (MJ) experienced worsened symptoms, highlighting the complex effects of marijuana on mood regulation.

Keywords:

bipolar disorder comorbidity ecological momentary assessment marijuana mood

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Area of Science:

Psychiatry
Neuroscience
Clinical Psychology

Background:

Bipolar disorder (BP) patients frequently report subjective mood benefits from marijuana (MJ) use.
Empirical evidence supporting MJ's mood-altering effects in BP patients is lacking.

Purpose of the Study:

To investigate the impact of MJ use on mood in individuals with bipolar disorder who smoke MJ (MJBP).
To compare mood changes in MJBP patients with those of non-bipolar MJ smokers (MJ) and non-MJ-smoking BP patients.

Main Methods:

Ecological momentary assessment using Palm Pilot devices for mood ratings and MJ use tracking.
Inclusion of three groups: MJ-smoking bipolar patients (n=12), non-bipolar MJ smokers (n=20), and non-smoking bipolar patients (n=11).
Calculation of difference scores between pre- and post-MJ mood ratings.

Main Results:

MJBP group showed significant mood improvement across multiple clinical scales post-MJ use.
MJ group reported a slight worsening of symptoms after smoking MJ.
Total mood disturbance decreased in MJBP patients but increased in MJ patients.
MJBP patients, despite baseline worse mood, demonstrated post-MJ improvement compared to non-smoking BP patients.

Conclusions:

Empirical data support anecdotal reports of MJ alleviating mood symptoms in some bipolar patients.
MJ use has differential effects on mood in bipolar versus non-bipolar individuals.
Further research is crucial to understand MJ's role in managing bipolar disorder symptoms.