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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Pericarditis I: Introduction01:22

Pericarditis I: Introduction

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Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
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Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Updated: Sep 26, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Systemic Sclerosis (SSc) After COVID-19: A Case Report.

Arjun Chandra1, Bashar Kahaleh2

  • 1Internal Medicine, University of Toledo, Toledo, USA.

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|April 21, 2022
PubMed
Summary
This summary is machine-generated.

This case study details a patient who developed systemic sclerosis (SSc) after a SARS-CoV-2 infection. It highlights a rare post-viral autoimmune complication, emphasizing the need for awareness in rheumatology and infectious disease.

Keywords:
autoimmunitycovid-19molecular mimicrynetosisnetssars-cov-2systemic sclerosis

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Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Autoimmunology

Background:

  • Numerous autoimmune and rheumatological disorders have been linked to SARS-CoV-2 infection.
  • Systemic sclerosis (SSc) is a rare post-viral autoimmune complication.
  • Only one prior case of SSc post-SARS-CoV-2 infection has been reported.

Observation:

  • A 48-year-old female presented with symptoms including Raynaud's phenomenon, fatigue, xerostomia, dysphagia, and skin hyperpigmentation after COVID-19 pneumonia.
  • Physical exam revealed puffy fingers, sclerodactyly, and abnormal nailfold capillaries.
  • Laboratory tests showed a high antinuclear antibody (ANA) titer (>1:1280), with specific SSc-related antibodies being negative.

Findings:

  • Pulmonary function tests indicated reduced diffusion capacity with interstitial lung disease on CT scan.
  • Esophagogastroduodenoscopy revealed Barrett's esophagus.
  • The patient met the 2013 ACR-EULAR classification criteria for SSc.

Implications:

  • This case adds to the limited evidence associating SARS-CoV-2 infection with the development of systemic sclerosis.
  • It underscores the potential for novel autoimmune manifestations following viral infections.
  • Further research is warranted to understand the mechanisms and prevalence of SSc post-COVID-19.