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Related Experiment Video

Updated: Sep 26, 2025

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay
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USP13: Multiple Functions and Target Inhibition.

Xiaolong Li1, Ge Yang1, Wenyao Zhang1

  • 1Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing, China.

Frontiers in Cell and Developmental Biology
|April 21, 2022
PubMed
Summary
This summary is machine-generated.

Ubiquitin-specific protease 13 (USP13) regulates key cellular functions and its dysregulation is linked to diseases, especially cancer. This review covers USP13 structure, function, disease links, and inhibitor development for targeted therapies.

Keywords:
deubiquitinationdiseaseinhibitorstructureubiquitin-specific protease 13

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Ubiquitin-specific protease 13 (USP13) is a deubiquitinating enzyme crucial for cellular processes including metabolism, autophagy, DNA repair, and ERAD.
  • USP13 regulates diverse substrate proteins, and its dysregulation is implicated in disease pathogenesis, particularly in malignant tumors.

Purpose of the Study:

  • To provide a comprehensive overview of USP13's structure, function, and disease associations.
  • To summarize recent advances in the discovery and development of USP13 inhibitors.
  • To offer a theoretical basis for understanding USP13's molecular mechanisms and developing novel inhibitors.

Main Methods:

  • Literature review of recent advances in USP13 research.
  • Analysis of USP13's role in various cellular processes and disease states.
  • Compilation of information on USP13 inhibitor discovery and development.

Main Results:

  • USP13 plays a significant role in stabilizing disease-related proteins and cancer targets.
  • Considerable efforts are underway to discover and develop USP13 inhibitors.
  • Understanding USP13's molecular mechanisms is key for developing potent inhibitors.

Conclusions:

  • USP13 is a critical enzyme with implications in numerous diseases, especially cancer.
  • Targeting USP13 holds promise for cancer therapy.
  • Further research into USP13 inhibitors is warranted for therapeutic development.