Prevalence of sleep disorders in children with chronic kidney disease: a meta-analysis
Kun-Tai Kang1,2,3, Ming-Tzer Lin4,5, Yin-Cheng Chen1,6
1Institute of Health Policy and Management, College of Public Health, National Taiwan University, Room 639, No. 17, Xu-Zhou Rd., Taipei, 10055, Taiwan.
Insights
Sleep disorders are common in children with chronic kidney disease (CKD). Children on dialysis show significantly higher rates of excessive daytime sleepiness and other sleep issues compared to those not on dialysis.
Area of Science:
- Pediatric Nephrology
- Sleep Medicine
- Public Health
Background:
- Prevalence of sleep disorders in pediatric chronic kidney disease (CKD) patients is highly variable.
- A quantitative meta-analysis is needed to accurately estimate sleep disorder prevalence in this population.
Purpose of the Study:
- To estimate the prevalence of various sleep disorders in children with CKD.
- To compare sleep disorder prevalence between children with CKD on dialysis versus those not on dialysis.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, MEDLINE, EMBASE, Cochrane) up to June 2021.
- Meta-analysis using a random-effects model to pool prevalence data from 12 eligible studies involving 595 children.
- Subgroup analyses were performed to compare prevalence rates based on dialysis status.
Main Results:
- Pooled prevalence rates: Restless legs syndrome (21%), sleep-disordered breathing (22%), pediatric obstructive sleep apnea (34%), excessive daytime sleepiness (27%), and insomnia/insufficient sleep (14%).
- Excessive daytime sleepiness prevalence was significantly higher in children on dialysis (43.3%) compared to those not on dialysis (11.2%).
- Children with CKD had increased risks for restless legs syndrome (3.9-fold) and excessive daytime sleepiness (9.6-fold) versus controls.
Conclusions:
- Sleep disorders are highly prevalent in children with CKD.
- Children on dialysis experience a significantly higher prevalence of excessive daytime sleepiness and other sleep disturbances.
- Findings highlight the need for increased awareness and management of sleep disorders in pediatric CKD patients.
Background:
The reported prevalence of sleep disorders in children with chronic kidney disease (CKD) varies greatly. A quantitative meta-analysis to estimate the prevalence of sleep disorders among pediatric CKD patients may provide further information.
Objectives:
The objective of this study is to estimate the prevalence of sleep disorders in children with CKD. The study protocol was registered on PROSPERO (registration number CRD42021268378).
Data Sources:
Two authors independently searched the PubMed, MEDLINE, EMBASE, and Cochrane review databases up to June 2021.
Study Eligibility Criteria:
Eligible studies include data of prevalence of sleep disorders in children with CKD.
Study Appraisal And Synthesis Methods:
The prevalence of restless legs syndrome, sleep-disordered breathing, pediatric obstructive sleep apnea (i.e., apnea-hypopnea index > 1 event/h in polysomnography), excessive daytime sleepiness, and insomnia/insufficient sleep was estimated using a random-effects model. Subgroup analyses were conducted to compare the prevalence of sleep disorders between children on dialysis and not on dialysis. This meta-analysis included 12 studies with 595 children (mean age: 12.9 years; gender ratio: 55.6% boys; mean sample size: 49.6 patients).
Results:
The prevalence of restless legs syndrome in children with CKD was 21% (95% confidence interval [CI], 14-30%). The prevalence of sleep-disordered breathing, pediatric obstructive sleep apnea, excessive daytime sleepiness, and insomnia/insufficient sleep was 22% (95% CI, 12-36%), 34% (95% CI, 19-53%), 27% (95% CI, 17-41%), and 14% (95% CI, 7-27%), respectively. Subgroup analysis revealed the pooled prevalence of excessive daytime sleepiness was significantly higher in children on dialysis than in children not on dialysis (43.3% vs. 11.2%; P = 0.018). Children on dialysis also had a high prevalence of other sleeping disorders, although the differences did not reach statistical significance. Children with CKD exhibited a 3.9-fold (95% CI, 1.37 to 10.93) increased risk of restless legs syndrome and a 9.6-fold (95% CI, 3.57 to 25.76) increased risk of excessive daytime sleepiness compared with controls.
Limitations:
The selected papers are of small sample size, lack of a control group, and exhibit substantial heterogeneity.
Conclusions:
Sleep disorders are common in children with CKD. Our results indicate that while the prevalence rates of various sleep disorders were higher in children on dialysis than in children not on dialysis, the prevalence of excessive daytime sleepiness was statistically significant in children on dialysis. A higher resolution version of the Graphical abstract is available as Supplementary information.
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