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Alginate-Based Hydrogels and Tubes, as Biological Macromolecule-Based Platforms for Peripheral Nerve Tissue
Walid Kamal Abdelbasset1,2, Saade Abdalkareem Jasim3, Satish Kumar Sharma4
1Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, P.O. Box. 173, Al-Kharj, 11942, Saudi Arabia. walidkamal.wr@gmail.com.
Annals of Biomedical Engineering
|April 21, 2022
Summary
Alginate-based neural guidance channels (NGCs) and hydrogels show promise for peripheral nervous system (PNS) injury repair, offering biocompatible solutions for nerve regeneration challenges.
Area of Science:
- Biomaterials Science
- Neuroscience
- Regenerative Medicine
Background:
- Peripheral nervous system (PNS) injuries can be challenging to repair, especially large defects.
- Autologous nerve grafting is a common but imperfect solution for bridging nerve gaps.
- Neural guidance channels (NGCs) and hydrogels are advanced therapeutic strategies for PNS repair.
Purpose of the Study:
- To review the applications of alginate-based NGCs and hydrogels in PNS injury repair.
- To discuss the challenges and future perspectives of using alginate in this field.
- To highlight alginate's potential as a biomaterial for nerve tissue engineering.
Main Methods:
- Review of existing literature on alginate-based NGCs and hydrogels for PNS repair.
- Analysis of alginate's properties relevant to nerve regeneration.
- Discussion of clinical translation and future research directions.
Main Results:
- Alginate is a biocompatible, non-toxic, and non-immunogenic polysaccharide with tunable properties.
- Alginate-based NGCs and hydrogels have demonstrated promising results in preclinical studies for PNS repair.
- The review identifies key applications and challenges associated with alginate in this context.
Conclusions:
- Alginate is a highly suitable biomaterial for developing NGCs and hydrogels for PNS repair.
- Further research is needed to optimize alginate-based strategies and address current challenges.
- Alginate holds significant potential for advancing the field of peripheral nerve regeneration.
