Related Experiment Video

Updated: Sep 26, 2025

Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants
11:35

Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants

Published on: May 4, 2018

8.2K

Risk Factors for Carbapenem-resistant Pseudomonas aeruginosa Infection in Children

Lu Li1, Yanfeng Huang1, Qiqin Tang1

  • 1From the Department of Infectious Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.

The Pediatric Infectious Disease Journal
|April 21, 2022
PubMed

Insights

Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a growing threat in hospitals. Prior carbapenem exposure and bronchoscopy are key risk factors for CRPA infection in children, necessitating careful antimicrobial stewardship.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Carbapenem-resistant Pseudomonas aeruginosa (CRPA) presents a significant and increasing threat as a nosocomial infection.
  • Identifying risk factors for CRPA infection in pediatric populations is crucial for effective management.

Purpose of the Study:

  • To determine the specific risk factors associated with carbapenem-resistant Pseudomonas aeruginosa (CRPA) infection in children.
  • To investigate the role of antimicrobial use and invasive procedures in the development of CRPA.

Main Methods:

  • A retrospective cohort study was conducted involving pediatric patients with Pseudomonas aeruginosa infection from 2016 to 2020.
  • Propensity-score matching was used to compare patients with carbapenem-susceptible PA and CRPA.
  • Univariate and multivariate analyses were employed to identify independent risk factors for CRPA.

Main Results:

  • Prior exposure to carbapenems (OR: 0.102) and bronchoscopy (OR: 0.147) were identified as independent risk factors for CRPA infection.
  • Previous invasive therapy in the last year (OR: 0.353) and recent use of beta-lactams/beta-lactamase inhibitors (OR: 0.327) were also significant risk factors.
  • The study analyzed 172 pediatric patients with PA infection.

Conclusions:

  • Prior carbapenem exposure and bronchoscopy are significant risk factors for pediatric CRPA infections.
  • Invasive therapies and specific antimicrobial use patterns influence the spread of CRPA.
  • Clinical use of carbapenems requires careful consideration and potential restrictions to mitigate resistance.
Abstract

More Related Videos

Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung07:46

Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung

Published on: June 5, 2012

33.3K
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.2K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
359
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.4K
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
77
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
119
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
110
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
274