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No association between LDL receptor and CETP genetic variants and atorvastatin response in Jordanian hyperlipidemic

Malek Zihlif1, Suhad Otoum1, Mohammad Al Shhab1

  • 1Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan.

Drug Metabolism and Personalized Therapy
|April 21, 2022
PubMed

Insights

Genetic variants in LDLR and CETP influence baseline LDL levels but do not affect atorvastatin efficacy in Jordanian hyperlipidemic patients. This finding impacts personalized medicine approaches for cholesterol management.

Area of Science:

  • Pharmacogenomics
  • Cardiovascular Genetics
  • Lipid Metabolism

Background:

  • Atorvastatin is a widely prescribed statin for lowering low-density lipoproteins (LDL).
  • Genetic variations in cholesteryl ester transfer protein (CETP) and LDL receptor (LDLR) can influence cholesterol transport and drug response.
  • Understanding these genetic influences is crucial for optimizing hyperlipidemia treatment.

Purpose of the Study:

  • To investigate the impact of specific LDLR (AvaII) and CETP (TaqIb, Rs1532624) genetic variants on atorvastatin efficacy.
  • To assess the association of these variants with LDL reduction in Jordanian hyperlipidemic patients receiving 20 mg atorvastatin.

Main Methods:

  • Genotyping of LDLR AvaII and CETP TaqIb variants using polymerase chain reaction-restriction fragment length polymorphism.
  • Genotyping of CETP Rs1532624 variant via Sanger DNA sequencing.
  • Analysis of 150 hyperlipidemic patients from the University of Jordan Hospital.

Main Results:

  • Significant associations were observed between LDLR AvaII, CETP TaqIb, and Rs1532624 variants and baseline LDL levels (p < 0.05).
  • No significant association was found between any of the tested genetic variants and the reduction in LDL levels following atorvastatin therapy (p > 0.05).

Conclusions:

  • The studied LDLR and CETP genetic variants are associated with baseline LDL cholesterol levels in Jordanian hyperlipidemic patients.
  • These genetic variants do not appear to influence the efficacy of 20 mg atorvastatin treatment in this patient cohort.
Abstract

Keywords:
CETPJordaniansLDL receptor (LDLR)hyperlipidemiastatins

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