Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Evolution - Fast or Slow?

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...

Genetic Lingo

Genetic Lingo

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Language Development

Language Development

Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...

Conservation of Protein Domains Over Different Proteins

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...

Convergent Evolution

Convergent Evolution

Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Examining selection dynamics and limitations in multi-round protein selection of high diversity libraries.

Protein engineering, design & selection : PEDS·2026

Same author

Single-molecule kinetic exploration of functional sub-states in an evolving phosphotriesterase.

Nature communications·2026

Same author

Artificial allosteric protein switches with machine-learning-designed receptors.

Nature biotechnology·2026

Same author

Structural and evolutionary constraints of organophosphate resistance in dipteran carboxylesterases.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Fragment Screening and Structure-Guided Development of Heparanase Inhibitors Reveal Orthosteric and Allosteric Inhibition.

ACS medicinal chemistry letters·2026

Same author

Expanding the biocatalytic and oxidative landscape of the old yellow enzyme family.

Protein science : a publication of the Protein Society·2025

Search research articles

Related Experiment Video

Updated: Sep 26, 2025

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Published on: January 12, 2024

Evo-velocity: Protein language modeling accelerates the study of evolution.

Mahakaran Sandhu¹, Matthew A Spence¹, Colin J Jackson²

¹Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.

|April 21, 2022

Summary

Researchers developed evo-velocity, a new phylogenetic method using protein language modeling. This approach overcomes limitations in traditional evolutionary sequence analysis for modern biology.

More Related Videos

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Published on: February 17, 2023

A Practical Guide to Phylogenetics for Nonexperts

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

Related Experiment Videos

Last Updated: Sep 26, 2025

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Published on: January 12, 2024

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Published on: February 17, 2023

A Practical Guide to Phylogenetics for Nonexperts

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

Area of Science:

Evolutionary biology
Computational biology
Genomics

Background:

Understanding protein sequence evolution is a key challenge in modern biology.
Traditional phylogenetic analysis has limitations in accurately reconstructing evolutionary history.

Purpose of the Study:

To introduce a novel phylogenetic approach called evo-velocity.
To leverage protein language modeling to enhance evolutionary analysis.

Main Methods:

Development of the evo-velocity phylogenetic method.
Application of protein language modeling to analyze protein sequence evolution.

Main Results:

Evo-velocity overcomes many limitations inherent in traditional phylogenetic methods.
The study demonstrates a new way to study protein sequence evolution.

Conclusions:

Protein language modeling offers a powerful tool for advancing phylogenetic analysis.
Evo-velocity provides a novel framework for understanding the evolutionary dynamics of protein sequences.