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Generalized Tetanus in a Canadian Farmer Following Orthopedic Surgery

Utkarsh Chauhan1, Anukul Ghimire2, Milan Raval3

  • 1Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R7, Canada.

Infectious Disease Reports
|April 21, 2022
PubMed

Keywords:
Clostridium tetaniimmunoglobulinrisk factorstetanustrismusvaccination

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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