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lncRNA - Long Non-coding RNAs02:39

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Current Status of Epitranscriptomic Marks Affecting lncRNA Structures and Functions.

Henry E Miller1,2,3, Mirolyuba Ilieva4, Alexander J R Bishop1,2,5

  • 1Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX 78229, USA.

Non-Coding RNA
|April 21, 2022
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Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are abundant and their structures, influenced by epitranscriptomic marks, are key to their functions. This review explores the current understanding of lncRNA structures and functions through epitranscriptomics.

Keywords:
RNA-seqepitranscriptomicsgene expressionlncRNA

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Area of Science:

  • Molecular Biology
  • Genomics
  • RNA Biology

Background:

  • Long non-coding RNAs (lncRNAs) are a vast class of RNA molecules exceeding 200 nucleotides.
  • lncRNAs constitute a significant portion of the transcriptome, with numbers far exceeding protein-coding genes.
  • Elucidating lncRNA functions is challenging due to their sheer quantity and complex interactions with DNA, RNA, and proteins.

Purpose of the Study:

  • To review the current understanding of long non-coding RNA (lncRNA) structures.
  • To discuss how epitranscriptomic modifications influence lncRNA functions.
  • To highlight the importance of epitranscriptomics in deciphering lncRNA roles.

Main Methods:

  • Literature review of recent studies on lncRNA structure and function.
  • Focus on research integrating epitranscriptomics with lncRNA analysis.
  • Synthesis of findings on RNA modifications and their impact on lncRNA interactions.

Main Results:

  • lncRNA structure is intrinsically linked to their diverse biological functions.
  • Epitranscriptomic marks, such as N6-methyladenosine (m6A), significantly modulate lncRNA conformation and interactions.
  • These modifications provide a new layer of regulatory control over lncRNA activity.

Conclusions:

  • Epitranscriptomics is crucial for a comprehensive understanding of lncRNA biology.
  • Investigating RNA modifications offers novel insights into lncRNA-mediated cellular processes.
  • Future research should focus on mapping and functional characterization of epitranscriptomic marks on lncRNAs.