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Postprandial gastric function in pancreatic insufficiency.

P T Regan, J R Malagelada, E P Dimagno

    Gut
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Patients with pancreatic insufficiency show altered gastric secretion and emptying, leading to maldigestion. Treatment improved these functions, indicating secretory disturbances, not motor defects, are key in exocrine pancreatic insufficiency.

    Area of Science:

    • Gastroenterology
    • Digestive Physiology

    Background:

    • Exocrine pancreatic insufficiency (EPI) can cause maldigestion.
    • Gastric function abnormalities may contribute to EPI symptoms.

    Purpose of the Study:

    • To simultaneously measure postprandial gastric secretion and emptying in EPI patients.
    • To correlate gastric function with intraluminal duodenal changes.
    • To assess the impact of replacement therapy on gastric function in EPI.

    Main Methods:

    • Intestinal intubation and duodenal perfusion in 10 healthy controls and 10 EPI patients.
    • Administration of a solid-liquid test meal.
    • Measurements taken before and after pancreatic enzyme replacement therapy.

    Main Results:

    Related Experiment Videos

    • EPI patients had lower postprandial intraduodenal pH due to reduced bicarbonate output.
    • Significant reductions in gastric acid, pepsin, and total secretory outputs were observed in untreated EPI patients.
    • Absolute gastric emptying rates were lower in EPI patients, but fractional rates were similar.
    • Fasting and postprandial hypergastrinaemia were noted in EPI patients.

    Conclusions:

    • EPI is characterized by postprandial secretory disturbances, not primary gastric motor defects.
    • Reduced bicarbonate secretion contributes to duodenal acidity in EPI.
    • Pancreatic enzyme replacement therapy may normalize some gastric functions.