EGFR Targeting TKI-Related Skin Toxicities in a Patient with Darker Skin: A Case Report

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Arman Zereshkian1, Alia Thawer2,3, David M Hwang4

  • 1Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.

Current Oncology (Toronto, Ont.)
|April 21, 2022
PubMed

Insights

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) can cause skin issues. This case highlights EGFR-TKI skin toxicity in a patient with darker skin tones, addressing a gap in clinical representation.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are crucial in treating non-small cell lung carcinoma (NSCLC).
  • EGFR-TKI therapy frequently causes dermatological toxicities, significantly affecting patient quality of life.
  • Current literature and visual resources predominantly feature skin reactions in lighter skin tones, leaving a gap in understanding for patients with darker skin.

Observation:

  • A case study involving a female patient with darker skin tones diagnosed with metastatic non-small cell lung carcinoma (NSCLC) is presented.
  • The patient experienced skin toxicity secondary to EGFR-TKI treatment.
  • The clinical course and management of this specific dermatological reaction were documented.

Findings:

  • Dermatological reactions to EGFR-TKIs in patients with darker skin tones are underrepresented in medical literature.
  • Lack of representation can lead to misdiagnosis, undertreatment, or mistreatment of these common toxicities.
  • This case underscores the need for increased awareness and tailored clinical guidance for managing EGFR-TKI-induced skin toxicities across diverse skin tones.

Implications:

  • Highlights the critical need for improved clinical recognition and management of EGFR-TKI-related skin toxicities in patients with darker skin.
  • Emphasizes the importance of inclusive visual resources and literature to guide dermatological assessment and treatment.
  • Advocates for equitable patient care by addressing disparities in the understanding and treatment of cancer therapy side effects.
Keywords:
EGFR inhibitorsTKIdark skin tonelung cancerskin toxicity

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