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Graphene Coatings for Biomedical Implants
Published on: March 1, 2013
Graphene-Based Biosensors for Molecular Chronic Inflammatory Disease Biomarker Detection
Isidro Badillo-Ramírez1,2, Yojana J P Carreón2, Claudia Rodríguez-Almazán2,3
1Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
Insights
Graphene derivative materials offer advanced biosensing for early detection of chronic inflammatory diseases. These novel biosensors provide highly sensitive detection, improving diagnosis and patient care.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Medical Diagnostics
Background:
- Chronic inflammatory diseases cause significant global mortality.
- Accurate biomarker detection is crucial for improved diagnosis and patient management.
- Graphene derivative materials (GDMs) show promise for biosensor development.
Purpose of the Study:
- To review recent advances in GDMs for biosensor development.
- To explore the potential of GDMs in detecting chronic disease biomarkers.
- To highlight the integration of GDMs into smart biosensing devices.
Main Methods:
- Review of electrochemical and optical sensing methods utilizing GDMs.
- Analysis of GDM properties (chemical, electrical, mechanical, biocompatibility).
- Discussion of GDM surface modification for biomolecular recognition.
Main Results:
- GDMs enable simple, accurate, and sensitive biomarker detection.
- Biosensors achieve detection limits in the nano to atto range.
- GDMs facilitate the creation of robust, wearable, and smart biosensing devices.
Conclusions:
- GDMs are highly promising for developing next-generation biosensors.
- These biosensors can significantly enhance the early detection and monitoring of chronic diseases.
- Further integration of GDMs into wearable technology will advance remote patient care.
Abstract:
Chronic inflammatory diseases, such as cancer, diabetes mellitus, stroke, ischemic heart diseases, neurodegenerative conditions, and COVID-19 have had a high number of deaths worldwide in recent years. The accurate detection of the biomarkers for chronic inflammatory diseases can significantly improve diagnosis, as well as therapy and clinical care in patients. Graphene derivative materials (GDMs), such as pristine graphene (G), graphene oxide (GO), and reduced graphene oxide (rGO), have shown tremendous benefits for biosensing and in the development of novel biosensor devices. GDMs exhibit excellent chemical, electrical and mechanical properties, good biocompatibility, and the facility of surface modification for biomolecular recognition, opening new opportunities for simple, accurate, and sensitive detection of biomarkers. This review shows the recent advances, properties, and potentialities of GDMs for developing robust biosensors. We show the main electrochemical and optical-sensing methods based on GDMs, as well as their design and manufacture in order to integrate them into robust, wearable, remote, and smart biosensors devices. We also describe the current application of such methods and technologies for the biosensing of chronic disease biomarkers. We also describe the current application of such methods and technologies for the biosensing of chronic disease biomarkers with improved sensitivity, reaching limits of detection from the nano to atto range concentration.
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