A Forensic Diagnostic Algorithm for Drug-Related Deaths: A Case Series

Area of Science:

• Forensic Science
• Toxicology
• Medicine

Background:

• Drug-related fatalities necessitate standardized investigative protocols.
• Current methods, including scene findings and initial screening, are often insufficient for definitive interpretation.
• Variability in drug detection interpretation highlights the need for a comprehensive approach.

Purpose of the Study:

• To present a multidisciplinary approach for investigating drug-related deaths.
• To emphasize the necessity of complete autopsy and advanced toxicological analysis.
• To introduce a diagnostic algorithm for coroners and toxicologists.

Main Methods:

• Application of a multidisciplinary approach in eight drug-related death cases.
• Complete autopsy for organ, tissue, and body fluid sampling.
• Utilizing peripheral blood to minimize artifacts and collecting multiple specimens for comprehensive analysis.

Main Results:

• External examination and toxicological screening alone are insufficient for accurate interpretation.
• A complete autopsy and extensive sampling provide a clearer picture of substance distribution.
• The case-dependent selection of drugs and matrices is critical for effective investigation.

Conclusions:

• A comprehensive, multidisciplinary approach is vital for accurate diagnosis of drug-related fatalities.
• Standardization of toxicological investigations requires funding for method development, research, and technological improvement.
• A diagnostic algorithm aids coroners and toxicologists in drug-related death investigations.