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Cooperative catalysis by a single-atom enzyme-metal complex.

Xiaoyang Li1,2, Yufei Cao1, Kai Luo3

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Researchers created a novel single-atom enzyme-metal catalyst using a photochemical method. This hybrid catalyst demonstrates high efficiency in alkyl-alkyl cross-coupling reactions, outperforming traditional catalysts.

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Area of Science:

  • Catalysis
  • Biochemistry
  • Materials Science

Background:

  • Single-atom catalysts offer high activity and selectivity.
  • Enzyme-metal hybrids can drive challenging reactions.
  • Developing stable single-atom enzyme-metal complexes is crucial.

Purpose of the Study:

  • To develop a photochemical method for creating stable single-atom enzyme-metal complexes.
  • To investigate the catalytic performance of these novel hybrid catalysts.

Main Methods:

  • A photochemical approach was used to anchor single metal atoms onto enzyme-polymer conjugates.
  • Carbon radicals were generated on the conjugate to bind single metal atoms.
  • Palladium (Pd) was used as the single metal atom, achieving 4.0% mass loading with atomic dispersion.

Main Results:

  • The Pd-anchored enzyme complex exhibited atomic dispersion of Pd.
  • Cooperative catalysis between the lipase active site and single Pd atoms accelerated the reaction.
  • The hybrid catalyst achieved a turnover frequency (TOF) of 540 h-1 for alkyl-alkyl cross-coupling.
  • This efficiency was 300 times higher than the traditional catalyst Pd(OAc)2 under ambient conditions.

Conclusions:

  • The developed photochemical method successfully creates stable single-atom enzyme-metal complexes.
  • These hybrid catalysts show superior efficiency for specific cross-coupling reactions compared to traditional catalysts.
  • This work opens new avenues for designing advanced hybrid catalysts with enhanced performance.