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Updated: Sep 26, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Cellular senescence in cancers: relationship between bone marrow cancer and cellular senescence
Manizheh Sarikhani1, Masoumeh Firouzamandi2
1Biotechnology Section, Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. m_sarikhani@yahoo.com.
Introduction:
There are many factors and conditions that lead to cellular senescence. Replicative senescence and Hayflick phenomenon are the most important causes of cellular senescence. Senescent cells also lead to wound healing conditions resulting from injury and toxic conditions.
Material And Methods:
When a cell becomes senescent, it stops replication and begins to leak inflammatory signals before growth. It also alters the extracellular matrix and behavior of neighbor cells and even motivates them. This review was conducted to determine the association between senescence and bone marrow cancer.
Results:
The results showed that senescent cells have a short life span due to their self-destructive nature or natural removal from the body by the immune system. These signals are effective to a certain extent in regenerating the damaged cells when present in a transient state. Cellular senescence can decrease the risk of all cancers, including bone marrow cancer, ensuring that cells with significant DNA injury are prevented from replication.
Conclusion:
However, senescent cells increase in number as they age, which is very harmful over time. These cells extend into an older tissue for longer periods of time and form longer clusters in older tissues. Therefore, cellular senescence significantly contributes to aging.
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