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Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian

Oksana S Pogorielova1, Viktoriia V Korniienko2, Yaroslav D Chumachenko3

  • 1Department of Internal Medicine with Center of Respiratory Medicine, Sumy State University, Sumy 40007, Ukraine.

Cardiology Research and Practice
|April 22, 2022
PubMed

Insights

Matrix metalloproteinase-9 (MMP-9) influences atherosclerosis, a key factor in coronary artery disease (CAD). AG-genotype carriers showed a reduced risk of myocardial infarction (MI) in the Ukrainian population.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Biochemistry

Background:

  • Coronary artery disease (CAD) is a major cause of mortality in Europe, primarily driven by atherosclerosis.
  • Matrix metalloproteinase-9 (MMP-9) plays a role in all phases of atherosclerosis, potentially contributing to CAD development.

Purpose of the Study:

  • To investigate the association between MMP-9 and the development of CAD.
  • To analyze the influence of MMP-9 genetic variations and plasma levels on CAD in a Ukrainian population.

Main Methods:

  • Genotyping for the rs17567 polymorphic locus using real-time PCR.
  • Measurement of MMP-9 plasma concentration via ELISA.
  • Study included 25 patients with intact coronary arteries, 40 with acute coronary syndrome (ACS), and 63 with chronic coronary syndrome (CCS).

Main Results:

  • AG-genotype carriers exhibited a significantly lower risk of myocardial infarction (MI) (P=0.023; OR=0.299).
  • MMP-9 plasma concentration data was collected but not detailed in the abstract's main findings.

Conclusions:

  • The rs17567 polymorphism in MMP-9 may be associated with a reduced risk of MI in the studied Ukrainian population.
  • Further research is warranted to elucidate the precise role of MMP-9 in CAD pathogenesis and its clinical implications.

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