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Related Concept Videos

Overview of the Vascular System01:20

Overview of the Vascular System

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The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
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Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Aneurysm I: Introduction01:30

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Congenital Vascular Malformations: A Quick Recap.

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Vascular malformations are typically sporadic, but genetic studies aid if family history exists. Delayed presentation due to cultural dress codes highlights the need for better diagnostic and management strategies for these rare vascular conditions.

Keywords:
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Area of Science:

  • Vascular Surgery
  • Medical Genetics
  • Dermatology

Background:

  • Vascular malformations are congenital anomalies of blood vessels.
  • These can present as sporadic or familial cases.
  • Early diagnosis and management are crucial for optimal outcomes.

Observation:

  • A retrospective review of vascular malformation cases at Sultan Qaboos University Hospital (July 2014-December 2019).
  • Observed that most cases were sporadic.
  • Identified potential delays in presentation linked to cultural practices, specifically dress codes.

Findings:

  • The study provides an overview of vascular malformations encountered in the region.
  • Highlights the sporadic nature of the majority of cases.
  • Suggests molecular genetic studies are beneficial for patients with a family history.

Implications:

  • A proposed diagnostic and management algorithm can guide healthcare professionals in diagnosis, counseling, and referral.
  • Establishing a national registry for vascular malformations is recommended to improve research and patient support.
  • Addressing cultural factors influencing presentation time is important for timely intervention.