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Updated: Oct 12, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

[Thrombolytic treatment in the acute phase of myocardial infarction. Evaluation in 1986]

A Kher, P L Michel, M Samama

    Annales De Medecine Interne
    |January 1, 1986
    PubMed

    Insights

    Fibrinolytic therapy, including streptokinase (SK), effectively reduces myocardial infarction mortality and improves heart function. Newer agents show promise but may require additional procedures like angioplasty.

    Area of Science:

    • Cardiology
    • Thrombolytic Therapy

    Context:

    • Myocardial infarction (MI) involves intracoronary clots.
    • Fibrinolytic therapy aims to lyse these clots.

    Purpose:

    • To evaluate the efficacy of fibrinolytic agents in treating acute myocardial infarction.
    • To assess outcomes such as mortality, coronary reperfusion, and left ventricular function.

    Summary:

    • Prolonged intravenous streptokinase (SK) significantly reduced short-term mortality and improved left ventricular function.
    • Intracoronary SK achieved high reperfusion rates (60-90%) with low complication rates.
    • High-dose, brief-duration intravenous SK also improved reperfusion and ventricular function.
    • Newer fibrin-specific agents like T-PA demonstrated success in thrombolysis but had a reocclusion rate of ~20%.

    Impact:

    • Fibrinolytic therapy is a cornerstone in reducing mortality from myocardial infarction.
    • SK therapy offers significant benefits with manageable side effects.
    • Emerging fibrinolytic agents require further investigation and potential adjunctive therapies.

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