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Related Experiment Video

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Author Spotlight: Recreating Melanoma Complexity with Patient-Derived Organoids for Immunotherapy Evaluation

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Organoid Models for Precision Cancer Immunotherapy.

Cai-Ping Sun¹, Huan-Rong Lan², Xing-Liang Fang³

¹Department of Medical Oncology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, China.

Frontiers in Immunology

|April 22, 2022

Summary

Patient-derived organoids (PDOs) offer a better model for cancer immunotherapy research than traditional methods. These complex tumor models accurately mimic the tumor immune microenvironment (TIME), improving preclinical testing and personalized treatment strategies.

Keywords:

cancer immunotherapy organoid precision medicine tumor microenvironment

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Area of Science:

Oncology
Immunology
Biomedical Engineering

Background:

Conventional in vivo and 2D in vitro cancer models fail to fully replicate the complex tumor immune microenvironment (TIME).
Accurate modeling of the TIME is crucial for evaluating cancer immunotherapies due to the involvement of the immune system.
Physiomimetic models are needed to better assess immunotherapy efficacy.

Purpose of the Study:

To discuss organoid culture approaches for modeling the tumor immune microenvironment (TIME).
To highlight the application of complex tumor organoids in testing cancer immunotherapeutics.
To explore the potential of organoids in personalized cancer immunotherapy.

Main Methods:

Review of various organoid culture techniques for TIME modeling.
Discussion on incorporating endogenous and exogenous components (immune cells, CAFs, vasculature) into organoid models.
Analysis of organoid platforms for preclinical immunotherapy testing.

Main Results:

Tumor organoid models can effectively recapitulate the TIME by preserving or incorporating diverse cellular and stromal components.
Organoid platforms demonstrate potential in modeling dynamic interactions within the TIME.
These models can facilitate the evaluation of immunotherapy responses.

Conclusions:

Patient-derived organoids (PDOs) provide a more accurate and physiomimetic model for studying the tumor immune microenvironment (TIME).
Organoid culture platforms are valuable tools for preclinical testing of cancer immunotherapeutics.
Complex tumor organoids hold promise for advancing personalized cancer immunotherapy.