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Ameloblastic carcinoma: A case report and evaluation.

Adesh S Manchanda¹, Ramandeep S Narang¹, Ravneet S Nagi²

¹Department of Oral and Maxillofacial Pathology and Microbiology, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.

Journal of Oral and Maxillofacial Pathology : JOMFP

|April 22, 2022

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Ameloblastic carcinoma (AC), a rare odontogenic tumor, presents diagnostic challenges due to its variable histology and scarcity. This case highlights an extraosseous variant, emphasizing the need for molecular studies for better treatment and prognosis.

Area of Science:

Oral pathology
Oncology
Odontogenic neoplasms

Background:

Malignant odontogenic neoplasms, including ameloblastic carcinoma (AC), are rare and difficult to study.
AC shares histologic features with ameloblastoma but displays cellular atypia, leading to classification complexities and diagnostic challenges.

Observation:

This paper details an unusual case of an extraosseous variant of ameloblastic carcinoma.
The extraosseous AC presented with variable histopathological features, complicating diagnosis.

Findings:

The study underscores the diagnostic difficulties posed by rare malignant odontogenic tumors.
Histologic similarity to ameloblastoma coupled with cellular atypia characterizes AC.

Implications:

Keywords:

Ameloblastic carcinoma CK18 Ki-67 ameloblastoma

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Accurate diagnosis and classification of AC are crucial for effective treatment planning.
Further evidence-based case studies and molecular investigations are needed to improve therapeutic strategies and prognostic insights for AC.