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Updated: Sep 26, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
Published on: December 23, 2020
Epigenetic-related Effects of COVID-19 on Human Cells
Arezoo Faramarzi1, Reza Safaralizadeh1, Narges Dastmalchi2
1Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Abstract:
Epigenetics is related to the various pathways that show long-term impacts on the gene expression patterns without alterations in nucleotide sequences. Over the last decade, epigenetics advanced significantly in the science of biology, oncology, innate immunity as well as pathogens and infectious diseases. In the present paper, we aimed to review the relationships between COVID-19 and epigenetic alterations of the infected cells. Coronavirus is one of the known infectious diseases that causes respiratory infection, such as pneumonia and coughing, while in animals, it causes diarrhea and upper respiratory disorders. This virus could be transmitted human to human or human to an animal through droplets. It translocates via membrane ACE-2 exopeptidase into the host cells. In conclusion, hypomethylation of angiotensin II converting enzyme (ACE II) possibly upregulates its expression, enhancing the possibility of SARS-CoV-2 infection.
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