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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
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Recent Advances in Senotherapeutics Delivery

Ji Young Choi1,2, Samantha F Yee1, Tzvetelina Tchangalova1

  • 1Tissue Engineering and Biomaterials Laboratory, Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, Maryland, USA.

Tissue Engineering. Part B, Reviews
|April 22, 2022
PubMed

Insights

Senotherapy clears senescent cells (SnCs) to combat age-related diseases. This review explores senolytic delivery strategies and tissue-engineered models for effective senotherapeutic development.

Area of Science:

  • Gerontology and Cellular Biology
  • Biomedical Engineering
  • Pharmacology

Background:

  • Accumulated senescent cells (SnCs) contribute to age-related diseases.
  • Senolytics target SnCs, but tissue-specific delivery remains a challenge.
  • Senotherapy offers a promising therapeutic avenue for various human diseases.

Purpose of the Study:

  • To review current senotherapeutic options and biological insights.
  • To explore tissue-engineered models for senolytic testing.
  • To discuss effective tissue-specific delivery strategies for senotherapeutics.

Main Methods:

  • Literature review of senolytic compounds and delivery strategies.
  • Analysis of current senotherapeutic research and biological insights.
  • Exploration of in vitro tissue-engineered models for senolytic potency testing.

Main Results:

  • Senolytics show promise in reducing SnCs globally.
  • Effective tissue-specific delivery of senotherapeutics requires further investigation.
  • In vitro tissue-engineered models offer a platform for testing senolytic efficacy.

Conclusions:

  • Senotherapy is a key strategy for treating age-related diseases.
  • Developing targeted senolytic delivery systems is crucial for clinical translation.
  • Tissue-engineered models can accelerate the validation of novel senotherapeutics.
Keywords:
cellular senescencedrug deliverysenolyticsenomorphicsenotherapeuticstissue-engineered models

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