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Related Experiment Videos

Left ventricular receptors: physiological controllers or pathological curiosities?

I H Zucker

    Basic Research in Cardiology
    |November 1, 1986
    PubMed
    Summary
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    The Bezold-Jarisch reflex, triggered by ventricular receptors, significantly impacts cardiovascular control. Recent studies highlight its crucial role in regulating heart rate and blood pressure, especially during conditions like heart attack.

    Area of Science:

    • Cardiovascular Physiology
    • Neurocardiology

    Background:

    • Ventricular receptors are sensitive to mechanical and chemical stimuli.
    • The Bezold-Jarisch reflex, involving these receptors, causes hypotension and bradycardia.
    • These reflexes are implicated in conditions like coronary ischemia and heart failure.

    Purpose of the Study:

    • To review the role of ventricular receptors in cardiovascular reflex control.
    • To emphasize the significance of the Bezold-Jarisch reflex in recent research.
    • To explore the interaction of ventricular receptors with other regulatory systems.

    Main Methods:

    • Histological and electrophysiological descriptions of ventricular receptors.
    • Review of experimental studies on intracoronary and intravenous substance administration.

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  • Analysis of reflex effects on heart rate, peripheral resistance, and hemodynamics.

    • Main Results:

    • Stimulation of ventricular receptors affects skeletal muscle and coronary vascular resistance.
    • Humoral substances like prostaglandins and bradykinin can trigger Bezold-Jarisch-like responses.
    • Ventricular receptors interact with baroreceptors, modulating cardiovascular reflexes.
    • Receptor stimulation influences vasopressin, renin, and catecholamine release.

    Conclusions:

    • The Bezold-Jarisch reflex plays a more critical role in cardiovascular control than previously understood.
    • Ventricular receptors are important in pathophysiological states like myocardial infarction and heart failure.
    • Further research is needed to fully elucidate the role of ventricular receptors in disease.