Multi-strategic approaches for enhancing active transportation using self-emulsifying drug delivery system

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery
• Biopharmaceutics

Background:

• Oral drug delivery is preferred for chronic diseases, reducing the need for frequent injections of proteins like insulin.
• Biopharmaceutics Classification System (BCS) class II and IV drugs present challenges due to poor solubility and permeability.
• Biologics are susceptible to degradation by enzymes and bile salts in the gastrointestinal tract.

Purpose of the Study:

• To explore the potential of Self-Emulsifying Drug Delivery Systems (SEDDS) for enhancing oral drug absorption.
• To discuss strategies for improving the oral delivery of poorly permeable drugs.
• To review factors influencing drug permeation across intestinal membranes.

Main Methods:

• Review of theories governing SEDDS formation and drug release mechanisms.
• Discussion of drug modification techniques like hydrophobic ion pairing and complexation with phospholipids.
• Overview of the impact of polymers, fatty acid chain length, and zeta potential on drug permeation.

Main Results:

• SEDDS formulations enhance oral absorption by increasing membrane fluidity and overcoming physiological barriers.
• Drug modification techniques can improve entrapment efficiency for poorly permeable compounds.
• Formulation parameters like polymer use and fatty acid chain length influence intestinal permeation.

Conclusions:

• SEDDS offer a promising approach for oral delivery of challenging drug compounds, including biologics.
• Tailoring SEDDS formulations and employing drug modification strategies are crucial for effective oral absorption.
• Further understanding of factors influencing permeation can optimize drug delivery systems.