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CYPRUS VIRUS INFECTION: A RARE BUT LIFE-THREATENING DIAGNOSIS IN CHILDREN

Saverio La Bella1,2, Giovanna Scorrano1,2, Rita Greco1

  • 1From the Department of Pediatrics, Spirito Hospital, Azienda Sanitaria Locale, Pescara.

The Pediatric Infectious Disease Journal
|April 22, 2022
PubMed

Insights

Sandfly fever, caused by Cyprus virus, can lead to severe neurological symptoms like decreased consciousness in children. This diagnosis should be considered for unexplained acute encephalopathy, even outside endemic regions.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Virology

Background:

  • Acute encephalopathy in children presents a diagnostic challenge.
  • Sandfly fever virus (SFV) is a known cause of febrile illness.
  • Cyprus virus (CYPV) is a specific strain of SFV.

Purpose of the Study:

  • To report a case of Sandfly fever Cyprus virus in a child.
  • To highlight the neurological manifestations of CYPV infection.
  • To emphasize the importance of considering CYPV in the differential diagnosis of acute encephalopathy.

Main Methods:

  • Clinical case presentation.
  • Review of patient's symptoms and intensive care management.
  • Differential diagnosis considerations for acute encephalopathy.

Main Results:

  • A 3.8-year-old Italian girl presented with high fever and headache.
  • Neurological decline included decreased consciousness, apneas, and bradycardia.
  • The patient required intensive care and mechanical ventilation.

Conclusions:

  • Sandfly fever due to Cyprus virus should be considered in the differential diagnosis of unexplained acute encephalopathy in children.
  • This diagnosis is relevant even when the patient is outside a known endemic area.
  • Early consideration can aid in appropriate patient management and outcomes.

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