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Engineered nasal dry powder for the encapsulation of bioactive compounds
Alberto Baldelli1, Mohammed A Boraey2, Hale Oguzlu3
1Faculty of Land and Food Systems, The University of British Columbia, BC, Canada.
Drug Discovery Today
|April 22, 2022
Summary
Nasal dry powders offer a promising method for delivering stable bioactive compounds. Spray-drying techniques and specific excipients enhance drug stability, absorption, and residence time on the nasal mucosa.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Biotechnology
Background:
- Nasal drug delivery presents challenges in achieving stable bioactive compound delivery.
- Spray-drying (SD) is a viable technique for encapsulating compounds into dry powders.
- Excipients play a crucial role in optimizing nasal powder formulations.
Purpose of the Study:
- To review the potential of nasal dry powders for stable bioactive compound delivery.
- To explore spray-drying (SD) manufacturing techniques for nasal powder encapsulation.
- To discuss approved and experimental excipients for nasal powder formulations.
Main Methods:
- Literature review of nasal dry powder formulations.
- Analysis of spray-drying (SD) applications in pharmaceutical manufacturing.
- Evaluation of excipient roles in nasal drug delivery.
Main Results:
- Nasal dry powders can effectively deliver stable bioactive compounds.
- Spray-drying (SD) enables efficient encapsulation and particle engineering.
- Excipients like polymers (e.g., hydroxypropyl methylcellulose), sugars (e.g., mannitol), and amino acids (e.g., leucine) enhance mucoadhesion, stability, absorption, and aerosol performance.
Conclusions:
- Nasal dry powders, manufactured via spray-drying (SD), are a promising platform for stable bioactive compound delivery.
- Strategic selection of excipients is key to optimizing nasal powder performance, including residence time and drug absorption.
- Further research into excipient combinations can enhance the therapeutic efficacy of nasal drug delivery systems.
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