Recent advances in nanogold as a promising nanocarrier for curcumin delivery

Curcumin is a natural polyphenolic compound that has promising therapeutic benefits. However, curcumin suffers from low aqueous solubility and poor bioavailability following oral administration, which are severe constraints to its full therapeutic potential. An exciting approach to resolving such challenges has been to incorporate curcumin into gold nanoparticles (AuNPs) to improve its unfavorable physicochemical and biopharmaceutical properties. Growing evidence shows that AuNPs increase cytotoxicity and apoptotic effect of curcumin on cancer cells. Moreover, AuNPs has the potential to enhance curcumin's cellular uptake and antioxidant properties. In addition, numerous benefits have been suggested for exploiting the curcumin's gold (Au) NPs as simple preparation and functionalization. Therefore, we can take advantage of the nanogold combination with curcumin in several therapeutic methods like photothermal therapy and theranostic nanocarrier. Here, we focus on the therapeutic properties of Au/curcumin NPs and the way to improve biocompatibility and bioavailability for curcumin encapsulation, intending to enhance their anticancer and antioxidant capacities. The present review also discusses the utilization and impact of Au NPs as a drug/gene delivery system/platform and various methods for the synthesis of Au/curcumin NPs.