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First Recombinant High-Density Lipoprotein Particles Administration in a Severe ICU COVID-19 Patient, a Multi-Omics

Sébastien Tanaka1,2, Floran Begue2, Bryan Veeren2

  • 1AP-HP, Service d'Anesthésie-Réanimation, CHU Bichat-Claude Bernard, 75018 Paris, France.

Biomedicines
|April 23, 2022
PubMed

Insights

Recombinant HDL (rHDL) infusion in a severe COVID-19 patient showed functional improvements in HDL particles and reduced inflammatory markers. This suggests rHDL is a potential therapeutic strategy for COVID-19 patients.

Area of Science:

  • Cardiovascular Biology
  • Infectious Diseases
  • Nanomedicine

Background:

  • High-density lipoproteins (HDLs) possess endothelioprotective properties.
  • SARS-CoV-2 infection significantly reduces HDL-cholesterol (HDL-C) and impairs HDL functionality.
  • Investigating therapeutic interventions for COVID-19-induced HDL dysfunction is crucial.

Observation:

  • A multi-omic investigation was conducted on the first administration of recombinant HDL (rHDL) particles in a severe COVID-19 patient.
  • Plasma ApoA1 increased and HDL-C decreased post-rHDL injection, indicating functional reverse cholesterol transport.
  • The proportion of large HDL particles increased, and pro-inflammatory proteins within HDLs decreased.

Findings:

  • rHDL administration led to increased ApoA1 and decreased HDL-C, suggesting functional reverse cholesterol transport.
  • Proteomic analysis revealed reduced pro-inflammatory proteins in HDLs after rHDL infusion.
  • Serum amyloid A-1, inflammatory markers, and cytokines significantly decreased during rHDL infusion.

Implications:

  • Recombinant HDL infusion is feasible and demonstrates potential as a therapeutic strategy for COVID-19.
  • rHDL may help restore HDL functionality and mitigate the inflammatory response in severe COVID-19.
  • Further clinical exploration of rHDL in COVID-19 patients is warranted.

Keywords:
CER-001COVID-19HDLcase-reportcytokinesinflammationlipoproteinproteomicssepsis

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