Related Experiment Video

Updated: Sep 26, 2025

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
06:19

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

3.4K

Transient Receptor Potential (TRP) Channels: Markers and Therapeutic Targets for Cancer?

Maria Beatrice Morelli1, Consuelo Amantini2

  • 1School of Pharmacy, Section of Experimental Medicine, University of Camerino, 62032 Camerino, Italy.

Biomolecules
|April 23, 2022
PubMed

Insights

Transient Receptor Potential (TRP) channels are implicated in cancer progression. This special issue investigates their diverse roles in tumorigenesis and potential as therapeutic targets.

Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Transient Receptor Potential (TRP) channels form a diverse superfamily of ion channels.
  • TRP channels are involved in sensing environmental stimuli and maintaining cellular homeostasis.
  • Dysregulation of TRP channel activity is increasingly linked to various pathologies, including cancer.

Discussion:

  • This special issue focuses on the multifaceted roles of TRP channels in cancer.
  • It covers TRP channel involvement in tumor initiation, growth, metastasis, and angiogenesis.
  • The potential of TRP channels as diagnostic biomarkers and therapeutic targets in oncology is discussed.

Key Insights:

  • Specific TRP channels, such as TRPV6 and TRPC1, are upregulated in certain cancers, promoting cell proliferation and migration.
  • TRP channel activity influences calcium signaling pathways crucial for cancer cell survival and invasion.
  • Modulating TRP channel function presents a promising avenue for novel anti-cancer strategies.

Outlook:

  • Further research into TRP channel function in different cancer types is warranted.
  • Development of selective TRP channel modulators could lead to targeted cancer therapies.
  • Understanding TRP channel networks offers new perspectives for cancer treatment and prevention.

More Related Videos

Controllable Ion Channel Expression through Inducible Transient Transfection10:00

Controllable Ion Channel Expression through Inducible Transient Transfection

Published on: February 17, 2017

9.5K
A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

9.0K

Related Concept Videos

Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
7.7K
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
7.2K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.8K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.7K