Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium-binding proteins and secretion.

J C Hutton

    Cell Calcium
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Calcium ions (Ca) are crucial for exocytotic secretion in eukaryotic cells, regulating processes like membrane fusion. Further Ca-binding proteins may act as intracellular signal transducers during secretion.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas-Kidney Transplants.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
    Same author

    In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions.

    Diabetologia·2013
    Same author

    Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients.

    Clinical and experimental immunology·2012
    Same author

    Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients.

    Diabetologia·2012
    Same author

    An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age.

    Diabetologia·2011
    Same author

    Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals.

    Diabetes/metabolism research and reviews·2011
    Same journal

    Spatially multiplexed stimulation reveals nonlinear calcium signaling in platelets.

    Cell calcium·2026
    Same journal

    Calcium handling properties and arrhythmia vulnerability of cardiomyocytes from dystrophin-deficient mdx mice.

    Cell calcium·2026
    Same journal

    Molecular actors of the Calcium signaling in the endothelial-to-mesenchymal transition: poorly explored therapeutic targets.

    Cell calcium·2026
    Same journal

    High-throughput quantitation of pathogen-induced calcium signals captured through live-cell fluorescence microscopy.

    Cell calcium·2026
    Same journal

    A model for the complete sequence of the human voltage-gated calcium channel (Ca<sub>V</sub>1.2) in a lipid bilayer.

    Cell calcium·2026
    Same journal

    STIM1 but not STIM1L couples Ca<sup>2+</sup> extrusion to SOCE, promoting NFATc1 activation and human myotube growth.

    Cell calcium·2026
    See all related articles

    Area of Science:

    • Cell biology
    • Molecular biology
    • Biochemistry

    Background:

    • Calcium ions (Ca) are central regulators of exocytotic secretion in eukaryotic cells.
    • Elevated cytosolic Ca levels trigger various cellular responses, including membrane fusion.
    • Ca-binding proteins, such as calmodulin and protein kinase C, mediate many Ca-dependent cellular events.

    Purpose of the Study:

    • To investigate the role of Ca ions in the regulated pathway of exocytotic secretion.
    • To identify and understand the function of Ca-binding proteins involved in cellular secretion.

    Main Methods:

    • Studies on Ca-dependent association of proteins with intracellular membranes in secretory tissues.
    • Analysis of the nature and inter-relationships of these Ca-binding proteins.

    Related Experiment Videos

    Main Results:

    • Ca ions directly or indirectly increase cytosolic Ca levels, impacting granule biogenesis and membrane fusion.
    • Calmodulin and protein kinase C are key Ca-binding proteins involved in secretion.
    • Evidence suggests the existence of additional Ca-binding proteins acting as intracellular transducers.

    Conclusions:

    • Ca ions are essential for controlling exocytotic secretion through various cellular mechanisms.
    • Ca-binding proteins play a critical role in mediating Ca signals during secretion.
    • Further research into novel Ca-binding proteins could uncover new mechanisms of secretory control.